Side Effects


Although advances have been made in the treatment of testicular cancer, there are side effects associated with treating the condition. Because cancer treatments often damage healthy cells and tissues, along with the cancer cells, side effects are common. Side effects depend mainly on the type and extent of the treatment, and may not be the same for each man. They also can change from one treatment session to the next. Before treatment starts, your health care team will explain possible side effects and suggest ways to help you cope with them.

Surgery to remove retroperitoneal lymph nodes can damage the nerves that control ejaculation. If these nerves are damaged, when a male ejaculates, the sperm are not deposited outside the body but rather end up deposited in the bladder. This is known as retrograde ejaculation. It’s important to note that although this type of surgery interferes with ejaculation it does not affect a man’s ability to have sexual intercourse.

If both testicles are removed, sperm cells cannot be produced and a man becomes infertile. Also, without testicles, a man cannot produce testosterone. In most cases, it will be necessary to take testosterone supplements, either in the form of a patch or a pellet implanted under the skin.

One of the challenges with external radiation therapy is that, while it destroys cancer cells, it can destroy nearby healthy tissue. Although it’s not common, some men do have a skin reaction that looks and feels like a sunburn on the outside of their skin. This will gradually fade away. Other possible side effects include fatigue, nausea, and diarrhea.

Chemotherapy can also cause a variety of side effects, with the severity depending on the type of drugs given, the amount taken, and how long the treatment lasts. Side effects could include:

  • Hair loss
  • Mouth sores
  • An increased chance of infection because of reduced white blood cell counts
  • Bruising or bleeding easily because of reduced blood platelet counts
  • Tiredness because of reduced red blood cell counts
  • Loss of appetite
  • Nausea and vomiting
  • Diarrhea or constipation, or
  • Scarring of the lungs

The good news is that these side effects will gradually decrease after your treatment is completed. Meanwhile, your health care team will recommend lifestyle adjustments and medications that can help you handle the discomfort of side effects.